Adenoma–Carcinoma Sequence. Most colorectal tumors arise from pre-cancerous polyps that are broadly categorized as either traditional tubular adenomas or serrated polyps. Adenomas develop when normal mechanisms that regulate DNA repair and cell proliferation are altered.

Background: It is widely accepted that the adenoma-carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.

2024年2月12日 · The adenoma-carcinoma sequence refers to a stepwise pattern of mutational activation of oncogenes (e.g. K-ras) and inactivation of tumor suppressor genes (e.g. p53) that results in cancer. An oncogene is a gene that has the potential to cause cancer.

2023年11月30日 · A simplified version of the adenoma-carcinoma sequence is basically the conversion of normal colonic mucosa → benign adenoma → advanced adenoma → an invasive cancer. This sequence is due to a number of genetic mutations that cause inactivation of tumour suppressor genes and activation of various oncogenes, which promote tumour growth.

The adenoma-carcinoma sequence was proposed in the 1980s that described transformation of normal colorectal epithelium to an adenoma and ultimately to an invasive and metastatic tumor. Initial genetic changes start in an early adenoma and accumulate as it transforms to carcinoma.

The adenoma-carcinoma sequence is a concept that envisages the evolution of carcinoma of the colon and rectum by way of an intermediate benign entity, the adenoma. It is a hypothesis that is as time honored as any in medical science.

2002年11月5日 · It is widely accepted that the adenoma–carcinoma sequence represents the process by which most, if not all, colorectal cancers arise. The evidence supporting this hypothesis has increased rapidly in recent years and the purpose of this article is to review this evidence critically and highlight its clinical significance.

2019年6月25日 · Adenoma–Carcinoma Sequence Most colorectal tumors arise from precancerous polyps that are broadly categorized as either traditional tubular adenomas or serrated polyps. Adenomas develop when normal mechanisms that regulate DNA repair and cell proliferation are altered.

In this article the epidemiologic, pathologic, molecular, and clinical evidence for the adenoma-carcinoma sequence is reviewed.

2024年11月1日 · Colorectal cancer exemplifies this process through its well-described adenoma–carcinoma sequence, modeled previously using clustered regularly interspaced short palindromic repeats (CRISPR) to...