2024年8月14日 · There is an ongoing need for researchers and all stakeholders to better understand issues surrounding antibody characterization to improve the quality and reproducibility of research that employs these reagents.

2024年9月27日 · A critical review of the limitations posed by current preclinical animal models of Alzheimer's disease and of the oversimplistic assumptions proposed by the amyloid cascade hypothesis (ACH).

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2024年12月27日 · A genetic screen and combined bioinformatic analyses revealed multiple novel transcription factors and their hierarchical organization in coordinating mitochondrial biogenesis.

2020年8月6日 · Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models. Given the advances in high-throughput technologies and the projected increase in the availability of binding data, we found it especially timely to evaluate the current standards for performing and …

2024年11月13日 · New research shows that the neural circuit responsible for stabilising gaze can develop in the absence of motor neurons, contrary to a long-standing model in the field.

6 天之前 · Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

2024年10月7日 · Gene fusions are common mutations that have been linked to several types of cancer, most notably chronic myelogenous leukemia, which is a result of the BCR gene on chromosome 22 fusing with the ABL gene on chromosome 9 (Nowell and Hungerford, 1960). Identifying fusion genes, and investigating the molecular behavior of the chimeric fusion …