Xanthine dehydrogenase, also known as XDH, is a protein that, in humans, is encoded by the XDH gene. [ 5 ][ 6 ] Xanthine dehydrogenase belongs to the group of molybdenum -containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer.

Xanthine dehydrogenase (EC 1.17.1.4, XDH) is a typical and complex molybdenum-containing flavoprotein which has been extensively studied for over 110 years. This enzyme catalyzes the oxidation of purines, pterin and aldehydes with NAD + …

Xanthine dehydrogenase is an enzyme that is an interconvertible form of xanthine oxidase, playing a key role in the degradation of purines by converting hypoxanthine to xanthine and xanthine to uric acid.

Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.

Xanthine dehydrogenase (EC 1.17.1.4, XDH) is a typical and complex molybdenum-containing flavoprotein which has been extensively studied for over 110 years. This enzyme catalyzes the oxidation of purines, pterin and aldehydes with NAD+ or NADP+ as ...

Xanthine dehydrogenase (XDH) is the enzyme that normally converts hypoxanthine to xanthine as well as xanthine to uric acid. XDH is deficient in xanthinuria type Iand the responsible gene for type I has been localized to chromosome 2p22-23 ( Ichida et al., 1997 ).

The dehydrogenase form, named xanthine dehydrogenase (XDH), produces uric acid using NAD + as an electron acceptor; the other form of the enzyme is xanthine oxidase (XO), which transfers electrons to O 2 yielding O 2 −, H 2 O 2, and uric acid [5–7].

2016年8月18日 · Xanthine dehydrogenase (EC 1.17.1.4, XDH) is an old typical and complex molybdenum-containing flavoenzyme, which has been extensively studied for its biochemical and structural properties ever since 1902.

The mammallian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, EC 1.17.3.2.

Xanthine dehydrogenase/oxidase is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase. SNPs at the 5'-nucleotidase and xanthine oxidase genes influence the risk of noncirrhotic portal hypertension in HIV patients treated with didanosine.