Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. [1]

受体酪氨酸激酶(receptor tyrosine kinase, RTKs)RTKs是最大的一类酶联受体， 它既是受体，又是酶， 能够同配体结合，并将靶蛋白的酪氨酸残基磷酸化。 所有的RTKs都是由三个部分组成的：含有配体结合位点的细胞外结构域、单次跨膜的疏水α螺旋区、含有酪氨酸蛋白 ...

受体酪氨酸激酶 （RTKs）是最大的一类 酶联受体，它既是生长因子的受体，也是能够催化下游靶蛋白磷酸化的酶。 正常情况下，生长因子-RTKs介导的细胞信号通路参与正常细胞的生理功能；但是，肿瘤发生时能够促进肿瘤的发生发展。 RTKs目前报道共有58种，可分为20个家族。 而能够激活RTKs的生长因子则超过100种。 （注：在这里我们将所有能够激活RTKs的统称为“生长因子”）。 下表是RTKs的分类： 二、结构与功能. 所以的RTKs均有三个部分组成：含有配体（生 …

2023年8月31日 · As the name suggests, a receptor tyrosine kinase is a cell surface receptor that also has a tyrosine kinase activity. The signal binding domain of the receptor tyrosine kinase is on the cell surface, while the tyrosine kinase enzymatic activity resides in the cytoplasmic part of the protein (see figure above).

2022年9月26日 · Receptor tyrosine kinases (RTKs) constitute one class of transmembrane receptors and are characterized by their cytoplasmic regions' intrinsic tyrosine kinase activity. RTKs are expressed in tissues throughout the body during intrauterine development and adulthood and play a critical role in regulating cell differentiation, proliferation ...

Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands — mainly growth factors — play key roles in ...

2021年6月2日 · Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK...

Signal binding to membrane receptor tyrosine kinases (RTKs) activates an enzyme called a kinase. Learn how kinases initiate a signaling cascade that relays information to the nucleus.

2004年5月1日 · Receptor tyrosine kinases are a subclass of cell-surface growth-factor receptors with an intrinsic, ligand-controlled tyrosine-kinase activity. They regulate diverse functions in normal cells...

Receptor tyrosine kinases, or RTKs, are single membrane spanning receptors and are defined by the presence of tyrosine kinase activity as the main cytoplasmic constituent and initiator of signal transduction. There are 58 receptor tyrosine kinases encoded in the human genome, several of which are important in hormone signaling.