A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions.

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli. Recent advances have implicated the role of tyrosine kinases in the pathophysiology of cancer.

2022年8月16日 · Technically speaking, a tyrosine kinase is an enzyme that transfers a compound called a phosphate group from ATP — a molecule that stores energy — to a specific area on cell proteins. It helps transmit the signals that cause cells to grow and divide and to perform specific functions in the body such as burning energy.

2023年5月12日 · Tyrosine kinase inhibitors (TKIs) keep cancerous cells from growing and spreading. From a medical standpoint, tyrosine kinase inhibitors launched targeted therapy for cancer — therapy that targets cancerous cells without damaging or destroying healthy cells.

2022年9月26日 · Receptor tyrosine kinases (RTKs) constitute one class of transmembrane receptors and are characterized by their cytoplasmic regions' intrinsic tyrosine kinase activity. RTKs are expressed in tissues throughout the body during intrauterine development and adulthood and play a critical role in regulating cell differentiation, proliferation ...

2021年1月7日 · Tyrosine kinases execute their biological functions by controlling a variety of cellular responses, such as cell division, metabolism, migration, cell-cell and cell matrix adhesion, cell survival and apoptosis.

Tyrosine kinases execute their biological functions by controlling a variety of cellular responses, such as cell division, metabolism, migration, cell–cell and cell matrix adhesion, cell survival and apoptosis.