Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microtubules.

2023年11月1日 · Scientists have linked Alzheimer’s disease to tau protein irregularities in the brain. These irregularities cause tau to detach from microtubules, which then become weak and collapse. This...

2024年2月13日 · Two commercially available blood tests can detect abnormal tau in Alzheimer’s disease. These tests measure tau that has undergone molecular changes, known as hyperphosphorylation, creating abnormalities associated with Alzheimer’s disease. Specialized imaging tools can also be used to detect tau.

Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development. Recent research, however, shows that these proteins have been highly conserved ...

Tau primarily provides stabilization to microtubules in the part of axons and dendrites. However, tau in a pathological state becomes hyperphosphorylated, causing tau dysfunction and leading to synaptic impairment and degeneration of neurons.

2020年11月15日 · This review will divulge the importance of tau in AD pathogenesis, the interplay of Aβ and tau, the pathological functions of tau, and potential therapeutic strategies for an effective management of neuronal disorders.

2020年11月15日 · Targeting these pathological functions of tau protein can be an effective strategy to create tau-based therapeutics in managing Alzheimer’s disease. Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss and cognitive insufficiency.

2025年2月6日 · Mar. 30, 2022 — In the course of Alzheimer's disease, two proteins called 'amyloid' and 'tau' accumulate in the brain. A new study with more than 200 participants now provides insights into the ...

2015年3月23日 · — By examining more than 3,600 postmortem brains, researchers at Mayo Clinic’s campuses in Jacksonville, Florida, and Rochester, Minnesota, have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer’s disease.

3 天之前 · A complementary drug to combat Alzheimer's disease could target a specific part of the nerve cell protein tau. This is the finding of research from the University of Gothenburg, which also offers ...