The American Physiological Society Journal publishes research articles on various aspects of physiology, including mathematical modeling, comparative physiology, and educational advancements.

As in inflammatory pain, neuropathic pain conditions give rise to phenomena such as allodynia and hyperalgesia, and as discussed below, calcium-permeable ion channels play important roles in this process.

2012年5月30日 · Although this sensory system was not specific to pain, La Forge’s drawing (based on Descartes’ concept and La Forge’s understanding of contemporaneous anatomy) of a foot near a flame is one of the most famous figures in neuroscience (Fig. 2). This example describes the pathway for promptly moving one’s foot away from a hot flame.

In neuropathic pain, targeting peripheral GABA-R has proven analgesic properties, which could be translated to itch. Central targets of itch act in the central nervous system and include the use of κ-opioid receptor (KOR) agonists and μ-opioid receptor (MOR) antagonists.

2020年6月30日 · kine signaling in latent and manifest spinal sensitization induced by two injections of nerve growth factor (NGF) into the lumbar multifidus muscle as a model for myofascial low back pain. Single dorsal horn neurons were recorded in vivo to study their receptive fields and spontaneous activity.

afferent pain pathway are permeable to calcium ions, suggesting a role in cell signaling beyond the mere generation of electrical activity. In this article, we provide a broad overview of different calcium-permeable ion channels in the afferent pain pathway and their role in pain pathophysiology. I. INTRODUCTION 81 II. ANATOMY OF THE AFFERENT ...

2023年6月28日 · However, some pathways and mediators associated with OA pain are more fully mapped, such as nerve growth factor (NGF)/tropomyosin receptor kinase A (TrkA), calcitonin gene-related peptide (CGRP), C–C motif chemokine ligands 2 (CCL2)/chemokine receptor 2 (CCR2) and tumor necrosis factor alpha (TNF-α), interleukin-1 β (IL-1β), the NOD-like ...

Emerging observations suggest several pain pathways that could be targeted to ameliorate or reduce pain. In this review, we describe the mechanisms of acute and chronic pain in SCD, focusing on how sickle pathobiology evokes pain by activating the peripheral and central nervous systems ( Fig. 1 ).

2016年6月3日 · Attenuation of neuropathic pain is achieved when near-normal dendritic spine profiles are successfully restored following a late treatment paradigm. Treatment cessation results in relapse of both neuropathic pain and abnormal dendritic spine profiles, with a marked increase in mushroom-shaped spine density and spine head diameter.

2020年6月25日 · neuropathic pain A. Rodent models of neuropathic pain and tools for testing mechanisms B. Tools for delineating functional contributions and studying plastic changes