Jan 1, 2021 · Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life. Examples include trigeminal neuralgia, painful polyneuropathy, postherpetic neuralgia, and central poststroke pain.

Mar 6, 2022 · Neuropathic pain reflects both peripheral and central sensitization mechanisms. Abnormal signals arise not only from injured axons but also from the intact nociceptors that share the innervation territory of the injured nerve.

In neuropathic pain, loss of Potassium-Chloride Cotransporter (KCC2) functional expression in spinal cord dorsal horn neurons contributes to GABAergic disinhibition. KCC2 expels chloride ions out of the neurons and hence guarantees a low intracellular chloride concentration, which is needed for proper GABAergic transmission.

Feb 5, 2014 · Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and along nociceptive and descending modulatory pathways in the central nervous system. The myriad neurotransmitters and other substances involved in the development and maintenance of neuropathic pain …

Jan 16, 2023 · The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest …

Jan 1, 2014 · There are a number of mechanisms of peripheral neuropathic pain, including peripheral neuronal sensitization, spontaneous ectopic electrical discharges, collateral sprouting, and ephaptic communication.

Feb 5, 2014 · This review focuses on the mechanisms of neuropathic pain, with special emphasis on clinical implications. Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and along nociceptive and descending modulatory pathways in the central nervous system.

Peripheral neuropathic pain is more common than central neuropathic pain, and is supposed to result from peripheral mechanisms, following nerve injury. The animal models of neuropathic pain show extensive functional and structural changes occurring in neuronal and non-neuronal cells in response to peripheral nerve injury.

Examples of neuropathic pain include painful polyneuropathy, postherpetic neuralgia, trigeminal neuralgia, and post-stroke pain. Clinically, neuropathic pain is characterised by spontaneous ongoing or shooting pain and evoked amplified pain responses after noxious or …

Neuropathic pain reflects both peripheral and central sensitization mechanisms. Abnormal signals arise not only from injured axons but also from the intact nociceptors that share the innervation territory of the injured nerve.