In this review, we highlight key mechanisms governing the survival of post-mitotic neurons, while also detailing the physiological and pathological contexts in which neurons are capable of overcoming this high apoptotic threshold. Keywords: apoptosis, NPCs, neurons, neuronal maturation, JNK, Bcl-2, Apaf-1, caspase, XIAP, neurodegeneration.

2000年10月12日 · Neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. The principal molecular components of the apoptosis programme in neurons...

Apoptosis is a type of programmed cell death (PCD). The cytomorphological features of an apoptotic cell include shrinkage, chromosome condensation and DNA fragmentation [22, 23, 24].

We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.

2015年11月5日 · Neuronal apoptosis and survival are tightly controlled processes that regulate cell fate during the development of the central nervous system and its homeostasis throughout adulthood.

2020年11月8日 · Neuronal apoptosis and axon degeneration both occur naturally in development, but also contribute to the pathology of nervous system disease. Anti-apoptotic proteins such as BCL-X L and BCL-W...

Neuronal apoptosis is an important process during the development of the nervous system, eliminating cells that make improper connections. Competition for growth factors is believed to regulate, at least in part, the process of neuronal apoptosis and survival.

Neuronal apoptosis has a significant role in the structuring of the developing neuron while mature neurons do not undergo apoptotic changes in normal conditions. Neuronal apoptosis is triggered by the activation of extrinsic (or death receptor) or intrinsic (or mitochondrial) pathways.

2019年6月23日 · In this review, we highlight key mechanisms governing the survival of post-mitotic neurons, while also detailing the physiological and pathological contexts in which neurons are capable of overcoming this high apoptotic threshold.

2000年10月12日 · Neuronal apoptosis sculpts the developing brain and has a potentially important role in neurodegenerative diseases. The principal molecular components of the apoptosis programme in neurons include Apaf-1 (apoptotic protease-activating factor 1) and proteins of the Bcl-2 and caspase families.