- In this article, we introduce the various stages of mouse thymocyte development and highlight recent work using various in vivo, and, where appropriate, in vitro models of T cell development that l...了解详细信息：In this article, we introduce the various stages of mouse thymocyte development and highlight recent work using various in vivo, and, where appropriate, in vitro models of T cell development that l...pubmed.ncbi.nlm.nih.gov/24748636/
MHC class-specific functions of CD4 + T helper cells, CD8 + killer T cells and CD4 + regulatory T cells are also established in the thymus. Finally, the thymus provides signals for...
www.nature.com/articles/s41577-023-00911-8The thymus hosts the development of a specific type of adaptive immune cells called T cells. T cells orchestrate the adaptive immune response through recognition of antigen by the highly variable T-cell receptor (TCR).
pmc.ncbi.nlm.nih.gov/articles/PMC8069328/The Notch signal transduction pathway is not unique to developing T cells, but in the development of blood cells its most prominent role is to induce a T-cell gene program in MPP cells that arrive in the thymus . In many other tissues and organs, Notch signaling similarly regulates cell fate determination.
pmc.ncbi.nlm.nih.gov/articles/PMC5583695/Here we applied CITE-seq to measure RNA and surface proteins in thymocytes from wild-type and T cell lineage-restricted mice to generate a comprehensive timeline of cell states for each T...
www.nature.com/articles/s41590-023-01584-0 A guide to thymic selection of T cells - Nature
2023年7月18日 · MHC class-specific functions of CD4 + T helper cells, CD8 + killer T cells and CD4 + regulatory T cells are also established in the thymus. Finally, the thymus provides …
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Single-cell multiomic analy…
Here we applied CITE-seq to measure RNA and surface proteins in thymocytes from …
Modeling the development o…
The current view of thymocyte developmental flow in the thymus …
Modeling the Dynamics of T-Cell Development in the Thymus
The thymus hosts the development of a specific type of adaptive immune cells called T cells. T cells orchestrate the adaptive immune response through recognition of antigen by the highly …
The development of T cells from stem cells in mice and humans
The Notch signal transduction pathway is not unique to developing T cells, but in the development of blood cells its most prominent role is to induce a T-cell gene program in MPP cells that …
Single-cell multiomic analysis of thymocyte development ... - Nature
2023年8月14日 · Here we applied CITE-seq to measure RNA and surface proteins in thymocytes from wild-type and T cell lineage-restricted mice to generate a comprehensive timeline of cell …
An overview of the intrathymic intricacies of T cell development
2014年5月1日 · The generation of a functional and diverse repertoire of T cells occurs in the thymus from precursors arriving from the bone marrow. In this article, we introduce the various …
- 作者: Divya K. Shah, Juan Carlos Zúñiga-Pflücker
- Publish Year: 2014
Single-cell insights into the hematopoietic generation of T …
2021年3月1日 · Mice and humans also differ in the timing of their first waves of T-cell development relative to gestation. In mice, with a 20-day gestation period, T-cell development …
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T-cell development in thymus | British Society for …
αβ T cell development, showing the different cell surface markers expressed at the different stages of T cell development in the mouse. DP cells rearrange their TCR-α chain loci, to produce an αβ-TCR. These cells then undergo positive …
Modeling the development of the post-natal mouse …
2016年11月8日 · The current view of thymocyte developmental flow in the thymus indicates that bone marrow progenitors enter the thymus on a daily basis where they first generate DN thymocytes that subsequently ...
Transcriptional regulation of early T‐cell development …
2016年1月13日 · T-cell development occurs in multipotent progenitors arriving in the thymus, which provides a highly specialized microenvironment. Specification and sequential commitment processes to T cells begin...
The c-kit+ Maturation Pathway in Mouse Thymic T Cell …
Phenotypic and functional characterization of c-kit expression during intrathymic T cell development
