Kupffer cells, also known as stellate macrophages and Kupffer–Browicz cells, are specialized cells localized in the liver within the lumen of the liver sinusoids and are adhesive to their endothelial cells which make up the blood vessel walls.

2022年12月30日 · Kupffer cells are specialized macrophages found in the hepatic sinusoid, along with sinusoidal endothelial cells, Ito cells, and pit cells. Kupffer cells are amoeboid-shaped and are attached to the sinusoidal endothelial cells.

Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair.

Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.

Kupffer cells (KC), the resident macrophages of the liver, represent the largest population of mononuclear phagocytes in the body. Phenotypic, developmental, and functional aspects of these cells in steady state and in different diseases are the focus of this review.

2023年6月26日 · Kupffer Cells are specialized macrophages in the liver. Let's explore the definition, anatomy, and functions of Kupffer cells. Kupffer cells are mammalian bodies' most abundant tissue macrophages, constituting 80-90%. Also known as Kupffer-Browicz cells or stellate macrophages.

Kupffer cell, any of the stellate (star-shaped) cells in the linings of the liver sinusoids. The sinusoids are microscopic blood channels. The Kupffer cells are phagocytic, i.e., capable of ingestion of other cells and of foreign particles.

2017年3月20日 · Liver macrophages comprise Kupffer cells — which are self-maintaining, non-migratory tissue-resident phagocytes that originate from yolk sac-derived precursors during embryogenesis — and...

Kupffer cells are a subclass of macrophages that are localized in the liver that represent the largest population of tissue-resident macrophages in the body (Nguyen-Lefebvre and Horuzsko, 2015).

Kupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair.