The abnormally hyperphosphorylated tau not only loses its biological activity and disassociates from microtubules (MTs), but also promotes its polymerization. The soluble abnormal tau …

Experimental studies on tau derived from postmortem cortical extracts and brain interstitial fluid of tau-transgenic mice, as well as human AD cortices, have demonstrated that the presence of …

In Alzheimer's disease brain, tau is abnormally hyperphosphorylated to a stoichiometry of at least three-fold greater than normal tau, and in this altered state it is aggregated into paired helical …

2022年8月15日 · Our study, for the first time, revealed that pTau contributes to neuronal death by inducing necroptosis and inflammation, mediated by activating the RIPK1/RIPK3/MLKL and …

2022年5月16日 · We found that sequential hyperphosphorylation by protein kinase A in conjugation with either glycogen synthase kinase 3β or stress activated protein kinase 4 …

2016年1月6日 · Based on the biochemically diverse range of pathological tau proteins, a number of approaches have been proposed to develop new potential therapeutics. Here we discuss …

Phosphorylation of tau in particular enhances tautubulin interaction which otherwise detaches from tubulin during hyperphosphorylation. The reason behind their destabilization, detachment …

3 天之前 · Hyperphosphorylated tau loses its affinity for microtubules and can aggregate into neurofibrillary tangles, contributing not only to microtubule dysfunction but also to neuronal …

2020年10月6日 · Here we report the use of recombinant hyperphosphorylated tau (p-tau) to identify potential tauopathy therapeutics and risk factors. Hyperphosphorylation renders tau …

Accumulation of hyperphosphorylated tau was accompanied by neurite degeneration, loss of viable synapses and indicators of behavioral abnormalities. Our results demonstrate that …