G3BP1 Is a Tunable Switch that Triggers Phase Separation to ... - PubMed
2020年4月16日 · One prominent type of RNP granule is the stress granule (SG), a dynamic and reversible cytoplasmic assembly formed in eukaryotic cells in response to stress. Here, we …
Ubiquitination of G3BP1 mediates stress granule disassembly in a ...
2021年6月25日 · We found that ubiquitinated G3BP1 interacted with the endoplasmic reticulum–associated protein FAF2, which engaged the ubiquitin-dependent segregase …
Cell三篇文章揭示G3BP为核心的RNA-蛋白分子机制 - 网易
2020年4月17日 · Jude Children’s Research Hospital的 J. Paul Taylor 组，题目为 G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules。 杨培国 博士等 …
Ubiquitination of G3BP1 mediates stress granule disassembly in a …
2021年6月25日 · We found that ubiquitinated G3BP1 interacted with the endoplasmic reticulum–associated protein FAF2, which engaged the ubiquitin-dependent segregase …
G3BP1 Is a Tunable Switch that Triggers Phase Separation to …
2020年4月16日 · The molecular basis for stress granule assembly is a network of protein-RNA interactions with G3BP1 as the central node and molecular switch that triggers phase …
Application of stress granule core element G3BP1 in
2024年12月1日 · Ras-GTPase-activating protein-binding protein 1 (G3BP1) is a core component and crucial regulatory switch in stress granules (SGs). When the concentration of free RNA …
G3BP1/2-Targeting PROTAC Disrupts Stress Granules Dependent …
2024年12月22日 · In this study, we designed two small molecules, #129 and PROTAC (Proteolysis Targeting Chimera) degrader 129 (PT-129), which specifically target the NTF2L …
Axonal G3BP1 stress granule protein limits axonal mRNA
2018年8月22日 · G3BP1 aggregates within peripheral nerve axons in stress granule-like structures that decrease during regeneration, with a commensurate increase in …
Both G3BP1 and G3BP2 contribute to stress granule formation
Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a component of SGs that initiates the assembly of SGs by forming a multimer. In this study, we examined the role of …
G3BP1 promotes intermolecular RNA-RNA interactions during …
2025年2月6日 · G3BP1 and G3BP2 proteins are proposed to assemble stress granules through multivalent crosslinking of RNPs. We demonstrate that G3BP1 also has “condensate …