In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur. [1][2] …

2021年4月15日 · Enhancers are non-coding sequences in the genome that activate the expression of target genes transcribed by the RNA polymerase II (RNAPII). Enhancers can act …

It is estimated that the human genome contains hundreds of thousands of enhancers, so understanding these gene-regulatory elements is a crucial goal. Several fundamental …

Here, we give an overview of emerging principles of enhancer function, current models of enhancer architecture, genomic substrates from which enhancers emerge during evolution, …

2014年3月11日 · In this Review, we discuss how properties of enhancer sequences and chromatin are used to predict enhancers in genome-wide studies. We also cover recently …

Enhancers are cis-regulatory elements containing short DNA sequences that serve as binding sites for pioneer/regulatory transcription factors, thus orchestrating the regulation of genes …

2023年11月9日 · Using the ENCODE-rE2G model, we build an encyclopedia of enhancer-gene regulatory interactions in the human genome, which reveals global properties of enhancer …

Enhancer sequences act upon genes on the same DNA molecule; however, enhancer sequences can be located thousands of base pairs away from the transcription start site of the gene being...

2013年3月18日 · Enhancers are classically defined as cis -acting DNA sequences that can increase the transcription of genes. They generally function independently of orientation and at …

2018年5月11日 · Accumulating evidence suggests that enhancers regulate gene transcription by stimulating release of promoter-paused RNA polymerase II into productive elongation.