We recommend short-term diclofenac application for post-surgical and post-traumatic patients with wounds who would benefit from its antiphlogistic and analgesic effect. However, if wound healing is disturbed, the negative effect of diclofenac on fibroblasts should be considered.

2022年1月1日 · We observed that MEL and DCL synergistically promoted wound healing in rats and, interestingly, the optimized formulation exerted increased and significant activity in terms of wound closure (Fig. 2) and histopathological effects measured as re-epithelization, fibroblast proliferation, collagen deposition, inflammatory cell infiltration, and ...

2024年11月1日 · NLDCs exhibited better cell migration (in vitro), wound regeneration which in turn showed enhanced wound healing potential compared to diclofenac (positive control). Cell migration and wound closure in vitro was monitored by scratch assay. In vivo, a cold burn wound model was developed by direct exposure of the dorsal rat skin to liquid nitrogen.

MEL-DCL nano-complexes exhibited better regenerated epithelium, keratinization, epidermal proliferation, and granulation tissue formation, which in turn showed better wound healing activity compared to MEL, DCL, or positive control. The nano-complexes also showed significantly enhanced antioxidant activity.

Postoperative diclofenac treatment significantly inhibited collagen deposition in subcutaneous granulation tissue. Anastomotic strength and skin wound strength were not significantly affected. The ePTFE model is suitable for assessing the effect of …

2013年12月17日 · a day, cranial wounds received topical diclofenac gel administration and caudal wounds were washed with isotonic saline. After seven, 14 and 21 postoperative days, five animals were randomly chosen for macroscopic and microscopic wound analysis.

Fast diclofenac release is preferable because anti-inflammatory drugs suppress a persistent inflammatory response, leading to improved wound healing [80,81]. Biphasic pattern of diclofenac release involving the two stages is targeted to control the local inflammation and pain associated with a burn injury.

2024年11月1日 · NLDCs exhibited better cell migration (in vitro), wound regeneration which in turn showed enhanced wound healing potential compared to diclofenac (positive control). Cell migration and wound closure in vitro was monitored by scratch assay. In vivo, a cold burn wound model was developed by direct exposure of the dorsal rat skin to liquid nitrogen.

2022年1月1日 · MEL-DCL nano-complexes exhibited better regenerated epithelium, keratinization, epidermal proliferation, and granulation tissue formation, which in turn showed better wound healing activity compared to MEL, DCL, or positive control. The nano-complexes also showed significantly enhanced antioxidant activity.

2 天之前 · Diclofenac sodium salt (DCF) was purchased from Sigma-Aldrich Co., Ltd. All other reagents were of analytical grade and were used without additional purification. 2.2. Synthesis of Carboxyethylated Phenol Red-Grafted Chitosan (CS-PR-AA) ... Wound healing is a complex regeneration process, which is characterised by intercalating degradation and ...