Beta catenin is a protein encoded by CTNNB1 gene with dual functions in cell adhesion and Wnt signaling

2022年1月3日 · Wnt/β-catenin signalling pathway has shown strong immunosuppressive function in a variety of tumours, and potentially become a novel target of tumour treatment. 300 Using …

Importantly, the β-catenin-binding site on α-catenin overlaps with α-catenin’s homodimerization interface, hence α-catenin can bind to adherens junctions only in its monomeric state …

Daniels DL, Weis WI. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nature structural & molecular biology. …

Ikeda S, Kishida S, Yamamoto H, Murai H, Koyama S, Kikuchi A. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator beta-catenin controls embryonic development and adult homeostasis. Here we review recent …

We discuss Wnt ligands, agonists, and antagonists, and their interactions with Wnt receptors. We also dissect critical events that regulate β-catenin stability, from Wnt receptors to the …

2022年1月3日 · The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

2004年9月1日 · Mutations linked to tuberous sclerosis activate β-catenin signalling. Even mutations in genes that modulate β-catenin signalling without any apparent link to WNT …

Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours