In eukaryotic cells, AMP-activated protein kinase (AMPK) generally promotes catabolic pathways that produce ATP and at the same time inhibits anabolic pathways involved in different …

2016年11月4日 · Recently, AMPK has been connected with apoptosis regulation, although the molecular mechanism by which AMPK induces and/or inhibits cell death is not clear. This …

In vivo, pharmacologic activation of AMPK led to massive apoptosis of RMICs and renal dysfunction in the setting of water deprivation in mice. Taken together, these results identify a …

2023年5月24日 · According to the current understanding, glucose-depleted cells induce autophagy through AMPK, the primary energy-sensing kinase, to acquire energy for survival. …

2022年10月31日 · In this Review, we provide an update on this canonical (AMP/ADP-dependent) activation mechanism, but focus mainly on recently described non-canonical pathways, …

Together with these findings, we discover that AMPK promotes apoptosis by phosphorylating apoptosis-stimulating of p53 protein 2 (ASPP2) in an irradiation (IR)-dependent manner and …

2024年3月30日 · Sustained activation of AMPK alleviates the PI3K/AKT/mTOR-mediated inhibition of autophagy and apoptosis, potentially underpinning the transition from autophagy …

2025年2月12日 · Morishita M, Kawamoto T, Hara H, Onishi Y, Ueha T, Minoda M, et al. AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent …

3 天之前 · Previous studies have established that apoptosis is one of the primary pathways through which ISL induces tumor cell death. Therefore, we proceeded to investigate the …

3 天之前 · Additionally, the expression levels of p-mTOR, p-AMPK, and P53 proteins in the shBLM group were decreased. The knockdown of BLM significantly inhibited cell proliferation, …