Objectives Beta-blockers and endoscopic variceal band ligation (VBL) have been preferred therapies for primary prophylaxis of variceal bleeding. However, the choice of therapy in patients with ...

Surveillance of hepatocellular carcinoma (HCC), via 6-monthly ultrasonography with alpha-fetoprotein testing, is currently ...

Background The large language model DeepSeek-R1 has received significant attention since it was released. The application in the healthcare sector has great potential owing to the localized deployment ...

Introduction Chronic hepatitis B (HBV) infection can cause liver cirrhosis and increases the risk of hepatocellular carcinoma. Consequently, there is a need to monitor even in asymptomatic inactive ...

Introduction Per-oral endoscopic myotomy (POEM) is becoming established practice for achalasia treatment and introduces a paradigm shift in traditional achalasia management. We evaluated interventions ...

Background Patients with Inflammatory bowel disease (IBD) have a high prevalence of depression. Gut microbiota dysbiosis has been reported to play an important role in IBD and depression. However, few ...

Objective To appraise the evidence that pathophysiological mechanisms and individualised treatment directed at those mechanisms provide an alternative approach to the treatment of patients with ...

Objectives We aimed to determine whether changes in acute severe colitis (ASC) management have translated to improved outcomes and to develop a simple model predicting steroid non-response on ...

The diet and gut microbiota have been extensively interrogated as a fuel for gut inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review how specific nutrients, ...

Background and aims A previous study of ours indicated that enhancer of zeste homologue 2 (EZH2) plays an important role in hepatocellular carcinoma (HCC) tumorigenesis. The aim of the present study ...

Introduction It has been surmised that cholecystitis develops in 3.5 – 12 % of cases after Endoscopic Retrograde Cholangiopancreatography (ERCP) deployment of self-expandable metal stent (SEMS) for ...

IDDF2024-ABS-0381 Bacteroides fragilis toxin suppresses METTL3-mediated m6A modification in macrophage to promote inflammatory bowel disease ...