Technological advances in the design and delivery of mRNA have catalysed the rapid development of mRNA COVID-19 vaccines by ...

Diazepam Nasal Spray is a seizure medicine that is often prescribed as a rescue medication for acute treatment of seizures outside of a hospital setting and can be administered by laypersons (people ...

AbbVie has signed a collaboration and licensing agreement with US-based ADARx Pharmaceuticals, committing $335m upfront to access its small interfering RNA (siRNA) platform. The partnership gives ...

Under the deal, ADARx will apply its proprietary siRNA discovery technology to identify and develop new molecular candidates. In addition, AbbVie will contribute expertise in antibody engineering, ...

AbbVie is paying ADARx Pharmaceuticals $335 million upfront to secure options on next-gen small interfering RNA (siRNA) therapeutics across several disease areas. The collaboration and license ...

AbbVie dipped its toes into the world of small interfering RNA last year with the buyout of Aliada Therapeutics. Now, the Illinois pharma is diving in further with a $335 million upfront payment to ...

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For the efficient cytoplasmic delivery of siRNA in a receptor-specific fashion, we designed a p19-YSA fusion protein composed of p19 RNA binding protein and ephrin mimetic peptide (YSA peptide). The ...

最后，siRNA-LNP 的制备过程复杂，需要专业技术和经验，不过目前其制备过程已较为成熟，具有良好的可重复性。 总体而言，本研究结果为未来利用 LNP 包裹的物种特异性 siRNA 操纵 PXB - 小鼠基因表达，创建包括疾病模型在内的新人源化模型提供了有价值的基础数据。

These specially selected siRNA bind to the virus’s genetic material to trigger a stronger antiviral response. Their findings were published in Nucleic Acids Research.