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定制化CRISPR来啦!高通量工程+机器学习解锁精准基因编辑,登Nature
蛋白质的工程改造和表征可能既耗时又繁琐,这促使人们开发通用型 CRISPR-Cas 酶,以实现多样化的基因组编辑应用。然而,这类酶也存在一些缺陷,例如脱靶编辑的风险较高。 为了实现 Cas9 酶的可扩展重编程,哈佛医学院(Harvard ...
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