During the oocyte-to-embryo transition (OET), the length of the mRNA poly(A) tail is closely linked to its translational efficiency. Regulation of the poly(A) tail is essential for selective ...

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

Moderna MRNA 0.14 % increase; green up pointing triangle was once a darling of the first Trump administration, which went to great lengths to help the company develop its Covid-19 vaccine that ...

In cultured human neurons, α-synuclein slowed mRNA degradation by physically interacting with key P-body proteins tasked with dismantling transcripts. In postmortem tissue from human frontal cortex, ...

In this GEN webinar, Scott Alderucci will discuss ways of leveraging new technologies and experimental design for an optimized, tailored approach to mRNA therapy development.

image: Poly(A) tail-mediated maternal mRNA remodeling during human oocyte-to-embryo transition view more . Credit: IGDB. Human development starts from the fertilization of a fully matured oocyte.

Schizophrenia affects around 200,000 people in the United States, and millions more worldwide; it can be a very serious disease. Little is known, however, about the mechanisms that underlie the ...

A team of researchers has observed sperm mRNA in newly fertilized eggs, according to a paper published in the May 13 Nature, in a finding that provides alternative explanations for mammalian ...

The Trump administration has canceled a contract awarded to Moderna for the late-stage development of its bird flu vaccine for humans, as well as the right to purchase shots, the drugmaker ...