Scientists from the Massachusetts Institute of Technology (MIT) say they have developed a simpler process for messenger RNA (mRNA) purification based on continuous precipitation. According to ...

2025年，全球mRNA疫苗累计接种已超百亿剂次，其高效性与安全性彻底改写了传染病防控的格局。从新冠疫苗到癌症治疗，mRNA技术正以惊人的速度渗透医学领域。然而，回溯至2005年，科学家Karikó团队首次发现，将mRNA中的尿苷（U）替换为假尿苷（ ...

The promise of mRNA technology seemed boundless after the success of the coronavirus vaccines, but Robert F. Kennedy Jr. has singled it out for scrutiny, clouding its prospects.

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, ...

Co-delivery of SpyC-mi3 and Pfs25-SpyT results in assembled particles displaying Pfs25 at high density. Credit: Nature Nanotechnology (2025). DOI: 10.1038/s41565-025-01889-1 ...

Smart mRNA drugs listen to the body, adjusting protein production based on disease-related signals by University of Osaka edited by Lisa Lock, reviewed by Robert Egan Editors' notes ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component ...

This review article provides a comprehensive overview of stress granules (SGs) —membraneless organelles formed in response to ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

More information: An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses, Science Immunology (2025). DOI: 10.1126/sciimmunol.ads1328 ...

Some notable examples of personalized mRNA products include Gritstone bio’s GRANITE and Moderna’s vaccine mRNA-4157, which are expected to enter the market in Q2 2027 and Q3 2030, respectively.

Using mRNA to stop HIV from hiding away in white blood cells could be the key to developing a way to eradicate the infection, rather than simply managing viral levels in the body. The tantalising ...