2025年，全球mRNA疫苗累计接种已超百亿剂次，其高效性与安全性彻底改写了传染病防控的格局。从新冠疫苗到癌症治疗，mRNA技术正以惊人的速度渗透医学领域。然而，回溯至2005年，科学家Karikó团队首次发现，将mRNA中的尿苷（U）替换为假尿苷（ ...

mRNA技术革新与疫苗设计 在COVID-19后时代，流感和SARS-CoV-2? 的共循环对公共卫生构成严峻挑战。mRNA技术凭借快速生产、模块化更新（如针对Omicron BA.4/BA.5变体）和双重抗原编码能力，成为开发组合疫苗的理想平台。

本文聚焦癌症 mRNA 疫苗，阐述其作为新兴免疫疗法，在临床应用中的进展与挑战。介绍了优化策略、作用机制、临床试验成果及联合疗法，分析现存问题并展望未来，为癌症免疫治疗研究提供全面参考。

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

In this GEN webinar, Scott Alderucci will discuss ways of leveraging new technologies and experimental design for an optimized, tailored approach to mRNA therapy development.

中国石药集团有限公司（CSPC Pharmaceutical Group Ltd）周三（3月22日）表示，中国已批准了其首款国内研发的针对COVID-19的mRNA（信使核糖核酸）疫苗。

The promise of mRNA technology seemed boundless after the success of the coronavirus vaccines, but Robert F. Kennedy Jr. has singled it out for scrutiny, clouding its prospects.

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

Circular mRNA, enhanced by an internal cap structure, can produce up to 200 times more protein than traditional methods, offering a stable and efficient translation process.

China's CanSino Biologics Inc has entered "test production phase" for its COVID-19 mRNA booster vaccine, the company said in a post on its social media account late on Thursday.