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超越凋亡,操控细胞死亡的“多面手”如何带来抗癌新方法 |《自然 ...
自1979年被发现以来,p53蛋白已成为了研究最为广泛和深入的肿瘤抑制因子之一。作为转录因子,p53调控众多下游信号通路,诱导细胞周期停滞、细胞凋亡和衰老是其最“经典”的功能,也被认为是其清除受损细胞、防止癌细胞发生的主要手段。学术经纬相关阅读:人类 ...
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