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优化狂犬病 mRNA 疫苗效能:结构域筛选与异源初免 - 加强免疫策略
它主要破坏人类和动物的中枢神经系统,给全球公共卫生带来了巨大威胁。目前,市面上的狂犬病疫苗主要包括灭活狂犬病病毒疫苗(IRV)、减毒活疫苗和病毒载体疫苗等。IRV 虽广泛应用,但存在诸多问题,比如需要多次注射,这不仅增加了接种者的负担 ...
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