RNA breaks destined for repair are inflicted by sequence-specific ... where a single multifunctional tRNA ligase enzyme (Trl1 in yeast; AtRNL in Arabidopsis) repairs the ends of the broken tRNA ...

Among the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA ...

“RNA-Seq [...] is expected to revolutionize the ... Jr. Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays. Science 296, 907–910 (2002).

Additionally, it highlights the crucial roles of enzymes and nucleic acids (DNA and RNA) in synthesizing proteins and regulating cellular functions. Ultimately, the interplay of these processes ...

but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in yeast represent transcriptional noise ...