想象一下，要在人类30亿个碱基对的基因组中，精确地测试成千上万个单一碱基突变的功能，这无异于大海捞针。传统的实验方法一次只能研究几个突变，效率极低，无法满足大规模筛选的需求。要破解同义突变之谜，首先需要一把能够高效、精准地在基因组上“动手术”的手术刀 ...

2025年6月25日，北京大学化学与分子工程学院的陈鹏团队与生命科学学院的伊成器团队在 Nature上发表了题为“RNA codon expansion via programmable pseudouridine editing and ...

Scientists have created an artificial RNA system that can copy itself using simple building blocks and temperature changes.

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

If you're studying genetics, molecular biology or a related field, odds are good that you will need to learn how to read a codon chart (aka codon table) to better understand the genetic code. This ...

When a ribosome cruises along messenger RNA (mRNA), it may stall at a particular codon, depending on which codons are nearby. In other words, codon context can influence the efficiency with which ...

One codon, two amino acids – it’s a unique set-up and further proof that the genetic code, universal though it almost is, is open to expansion and evolutionary change.

So in E.crassus, the UGA codon is not tied to a single fate - it has a choice. It can be interpreted in two different ways, depending on its location and that of the SECIS element that influences it.