猪繁殖与呼吸综合征病毒（PRRSV）突变率高，严重影响养猪业。研究人员针对 PRRSV 的 RNA 依赖的 RNA 聚合酶（RdRp）开展研究。结果发现 Val218 和 Pro386 是关键位点，影响病毒遗传稳定性和利巴韦林敏感性。这为设计稳定的高保真 PRRSV 疫苗提供理论依据。

Cleveland Clinic virology researchers have found that a specific protein modification to the immune protein MDA5 is key to how human bodies detect and respond to viruses and viral replication.

Key steps in the life cycle of HCV include entry into the host cell, uncoating of the viral genome, translation of viral proteins, viral genome replication, and the assembly and release of virions.

Discover how a structural breakthrough in the chikungunya virus is opening new avenues for antiviral drug development and ...

The RNA polymerase is responsible for the replication of viral genetic material and the activation of viral genes, and is ...

Scientists have now developed a new technology that has uncovered the underlying mechanism that has enabled them to calculate ...

To test whether nSMase2 is essential for viral replication, the team inhibited the enzyme by using an antiviral compound, [phenyl(R)-(1-(3-(3,4-dimethoxyphenyl)-2, ...

NTNU researchers identified an oral antiviral cocktail that blocks enterovirus replication in human cells and mini-organs. The combination, previously tested for safety, showed no adverse effects on ...

These drugs work by inhibiting the viral reverse transcriptase enzyme, preventing the replication of the viral genetic material ... Their importance extends beyond their role in DNA and RNA, as ...

This semiconservative replication ensures that each daughter cell receives an exact copy of the genetic information. RNA Synthesis (Transcription ... of functional genes into cells to replace or ...