为探究癌细胞如何应对肿瘤微环境中升高的氨水平，研究人员开展了 “低细胞外 pH 保护癌细胞免受氨毒性” 的研究。结果发现，氨抑制癌细胞生长，诱导基因组不稳定，抑制溶酶体介导的蛋白水解，低细胞外 pH 可抵消氨的这些影响，这对未来癌症治疗研究有重要意义。

"This discovery is an important step toward using natural biological tools to improve cancer treatment," says Hanayama, lead author of the study. "By using extracellular vesicles, we can enhance ...

The University of Alabama at Birmingham is accelerating spatial biology research with announcement of $160,000 worth of ...

Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

维生素 A 的主要活性代谢产物维甲酸（Retinoic Acid，RA），在 T 细胞亚群的分化和抗肿瘤免疫中有着重要作用。但此前，人们对其在缓解 γδ T 细胞免疫耗竭、促进抗肿瘤免疫方面的研究还相对较少。为了探索其中的奥秘，来自暨南大学附属第一医院等机构的研究人员开展了一系列研究，相关成果发表在《Cell Communication and Signaling》杂志上。

Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.