SGLT2 inhibitors, compared with GLP-1 RAs, were associated with lower risks for osteoarthritis and joint replacement surgery among patients with T2D.

HEAL-116 robustly inhibited 3βHSD1 activity and exerted pronounced antitumor effect in biochemical, cellular, and mouse models. Our findings lay the foundation for the clinical translation of 3βHSD1 ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...

Humans shape technologies, but our lives are then shaped by the technologies we create - for better or worse. Here's how to protect your mind and brain.

Initially used for blood glucose control, the medications reduce cardiovascular events and mitigate heart failure hospitalization, regardless of diabetes status.

Despite incomplete evidence, longevity enthusiasts are experimenting with SGLT2 inhibitors in their quest to live healthier for longer.

Patients with rheumatoid arthritis treated with Janus kinase inhibitors do not demonstrate increased risks for major cardiovascular complications vs. TNF inhibitors or other biologic disease ...

Janus kinase inhibitors are not associated with an increased risk for gastrointestinal perforation among adults with active rheumatoid arthritis.

Evotec International GmbH has divulged NLRP3 inflammasome inhibitors reported to be useful for the treatment of asthma, cryopyrin-associated periodic syndromes, hypertension, Alzheimer’s disease, ...

News Technostress: Orgs Give Employees AI, then Demand More Work By David Ramel 06/03/2025 Your new AI assistant might help you work faster -- but don't expect to go home earlier. A recent academic ...

Key Takeaways Precision medicine in prostate cancer utilizes genetic testing to identify patients for PARP inhibitor treatment, enhancing personalized care. Genetic testing, including germline and ...