*仅供医学专业人士阅读参考Tau蛋白异常聚积是神经退行性疾病的典型病理之一，不仅影响神经元功能，也有可能通过代谢重编程和炎症反应导致内皮细胞损伤和脑血管功能障碍。病理条件下，tau蛋白发生过度磷酸化，失去与微管的结合能力，逐渐聚集形成原纤维结构。原纤 ...

最近，天普大学阿尔茨海默病中心的研究团队发现，原纤维状tau蛋白可以通过增加糖酵解水平，诱导内皮屏障通透性，使内皮细胞表现促炎表型，连接蛋白表达受损。这项研究发表在《Alzheimer's & Dementia》杂志上。

近年来，神经退行性疾病的研究不断深入，尤其是tau蛋白的异常聚集引起了科学界的广泛关注。这种蛋白的聚积不仅影响神经元的正常运作，还可能通过改变代谢途径和诱发炎症反应，导致脑血管功能的障碍，从而影响血脑屏障（BBB）的完整性。

VY7523 anti-tau antibody: DISCRIMINATION OF ANTI-TAU ANTIBODIES TARGETING DIFFERENT TAU EPITOPES BY A P301S MOUSE HIPPOCAMPAL SEEDING MODEL OF TAUOPATHY. Wencheng Liu, Ph.D., ID:1403. New preclinical ...

DISCRIMINATION OF ANTI-TAU ANTIBODIES TARGETING DIFFERENT TAU EPITOPES BY A P301S MOUSE HIPPOCAMPAL SEEDING MODEL OF TAUOPATHY. Wencheng Liu, Ph.D., ID:1403. New preclinical data show that the ...

VY7523 anti-tau antibody: DISCRIMINATION OF ANTI-TAU ANTIBODIES TARGETING DIFFERENT TAU EPITOPES BY A P301S MOUSE HIPPOCAMPAL SEEDING MODEL OF TAUOPATHY. Wencheng Liu, Ph.D., ID:1403. New preclinical ...

Voyager Therapeutics (VYGR) reported new data from its two preclinical programs targeting tau for the treatment of Alzheimer’s disease. Data on ...

VY7523 anti-tau antibody: DISCRIMINATION OF ANTI-TAU ANTIBODIES TARGETING DIFFERENT TAU EPITOPES BY A P301S MOUSE HIPPOCAMPAL SEEDING MODEL OF TAUOPATHY. Wencheng Liu, Ph.D., ID:1403. New preclinical ...

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.