tfh依赖的tls的抗肿瘤作用是通过il-21-il-21受体信号转导实现的。 这些发现证实了Tfh细胞依赖的三级淋巴结构（TLS）在肺腺癌（LUAD）发生和发展中的抗 ...

Cell Res ：清华大学祁 ... 该研究揭示了B细胞来源的自身抗原是诱导自发生发中心的重要原因，BDAs特异性的B细胞受到TFH的帮助以及TFR的抑制，这三者 ...

来自国内的研究人员针对系统性红斑狼疮(sle)中滤泡辅助性t细胞(tfh)异常活化的难题，通过基因敲除和药物干预实验，揭示法尼醇x受体(fxr)通过调控胆固醇代谢控制tfh细胞增殖的新机制。使用临床获批药物熊去氧胆酸(udca)抑制fxr信号可显著缓解狼疮模型中的gc反应和自身抗体产生，为sle治疗提供全新 ...

该研究探讨组蛋白甲基转移酶 KMT2D 在抗病毒 CD4+T 细胞应答中的作用，发现其通过促进 TFH细胞形成及抗体反应、抑制细胞毒性 CD4+T（CD4CTL）细胞分化，揭示 KMT2D 在协调 TFH和细胞毒性 CD4+T ... 【字体： 大 中 小 】 时间：2025年06月03日 来源：Cell Reports 7.5.

A sustained appearance of the cell-surface protein, Tigit, identifies the Tigit-positive PD-1 + CXCR5 + CD4 + T cells, or pre-Tfh, that will become GC-Tfh cells, they report in a study published ...

TGF-β specifies T FH versus T H 17 cell fates in murine CD4 + T cells through c-Maf. Science Immunology , 2024; 9 (93) DOI: 10.1126/sciimmunol.add4818 Cite This Page : ...

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause ...

A recent investigation into the molecular roots of systemic lupus erythematosus may point the way toward a new generation of therapeutic targets, according to the researchers. The Nature paper ...

More information: Aidil Zaini et al, Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response, Mucosal Immunology (2023 ...

Thus, Tfh cell help is required for class-switched-specific BRM responses to influenza. What role do the Tfh cells play? The UAB researchers found that the preferential differentiation of lung-BRMs ...

In fact, JD Power told CNBC that the average cell phone bill is now $144. According to the St. Louis Federal Reserve , the Consumer Price Index of telephone services has increased 7% since Jan. 2019.

A new type of fuel cell that runs on sodium metal could one day help clean up sectors where it’s difficult to replace fossil fuels, like rail, regional aviation, and short-distance shipping.