Scientists identify stress granules as the potential root cause of Alzheimer's disease. This new understanding may ...

Arizona researchers present a unified theory of Alzheimer's disease, linking cellular stress granules to all known symptoms.

Mutations that stabilize stress granules reversed the effects of disease-causing mutations in test tubes and cells, pointing to a protective role of stress granules in neurodegenerative diseases.

Stress granules are biomolecular condensates that form under conditions of cellular stress and have been previously implicated as drivers of amyotrophic lateral sclerosis (ALS), frontotemporal ...

Stress granules (SGs) are transient organelles that form when cells experience stress, serving as critical hubs for RNA metabolism and cellular survival. Comprised of RNA-binding proteins and ...

Specifically, the researchers explored how the presence of these "stress granules" disrupt molecule movement between a cell's nucleus (the center part of a cell that contains genetic material) and ...

Their comparison revealed that older neurons had various hallmarks of molecular stress such as storing untranslated RNA and protein in stress granules—compartments outside of the cell’s nucleus.

As the paper explains, 'stress granules' are basically clumps of proteins and RNA (a nucleic acid in cells with similar structures to DNA) that form when a cell is under stress.

Stress granules are clusters of proteins that assemble inside cells exposed to stressful conditions, such as lack of oxygen, toxic agents or infections, and enable the cell to survive. The right dose ...