Oligo DNA design. The AS-ODN used was the reverse sequence of 20 bases of Rous sarcoma virus phosphoprotein p60 (src) gene (GenBank accession no. M84475), beginning from the first Met of v-src: 5 ...

Identification of an effective siRNA target sequence. Since there is considerable variability in the effectiveness of different siRNA sequences, our first objective was to identify a region of ...

View the Dinshaw Patel Lab page for siRNA and piRNA Biogenesis and Silencing . RNA interference is a conserved biological response to double-stranded RNA that regulates gene expression. The response ...

This improvement in siRNA stability is superior to that observed for other chemical modifications (e.g., 2'-O-methyl, locked nucleic acid and 2'-deoxy-2'-fluoro nucleotides) suggesting that ...

Strong Immune Response To New SiRNA Drugs In Development May Cause Toxic Side Effects Date: May 25, 2009 Source: Mary Ann Liebert, Inc./Genetic Engineering News ...

siRNA Patent Litigation So far, the two litigations involving ‘Tuschl’ patents – Max-Planck-Gesellschaft v. Whitehead Institute (2009) and the University of Utah v.

Using formamide, a group has succeeded in chemically altering siRNA to reduce the risks of these off-target effects, improving the safety of siRNA drugs for genetic therapy. Skip to main content ...

As a result, patent examination standards surrounding siRNA-related inventions have come under the spotlight in recent years. The China National Intellectual Property Administration (CNIPA) offered a ...

Nomura believes the research has potential applications as siRNA drugs for diseases such as hereditary transthyretin amyloidosis, acute hepatic porphyria, primary hyperoxaluria type 1, primary ...