Borzoi is a deep learning model that predicts RNA sequencing coverage across each exon of every human gene, across different cells and tissues, based on DNA sequence alone. We developed Paired ...

Figure 1: Dnmt1 actively represses transcription using sequences that overlap the HRX repression domain. Figure 2: Dnmt1 686–812 represses transcription in a TSA-sensitive manner and has the ...

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Achilles tendinopathy (AT) is a chronic degenerative tendinopathy that affects people’s daily lives. Multiple clinical studies have found that current conservative treatments fail to promote quality ...

compact repressor domains were identified through high-throughput screening of over 30,000 diverse domains across the tree of life Structural, functional, and sequence analyses provided novel ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

Signalling Research Centers BIOSS and CIBSS, Faculty of Biology, and SGBM - Spemann Graduate School of Biology and Medicine, University of Freiburg, Schänzlestrasse 18, 79104 Freiburg, Germany ...

The disease is caused by abnormal duplication of CAG in a specific DNA sequence within the Huntington gene. The higher the copy number, the earlier the disease manifests. The research team of Seiya ...

SaPIs reside passively in the host chromosome, under the control of the SaPI-encoded master repressor, Stl. It has been assumed that SaPI de-repression is effected by specific phage proteins that bind ...