How do bacteria avoid wasteful production of unnecessary proteins when their genes are always on? The answer lies in regulating the operon. As trp levels increase, trp binds to trpR, causing a ...

In the case of CAT, the upstream gene encodes a repressor protein, so making more of it represses the expression of CAT. The concept of a synonymous mutation impacting its own gene's processes has ...

Highlights from the oral presentation include: Scribe engineered novel, potent epigenetic editors (ELXRs) using newly identified repressor domains to durably and effectively silence gene ...