Feb. 7, 2025 — A research team has made a major discovery on how the CUL5 gene affects CAR-T cell therapy, an advanced cancer therapy. The study reveals that reducing the activity of the CUL5 ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

The researchers discovered that OsMED23, a component of the cellular "Mediator" complex that helps regulate gene activity, partners with a histone demethylase (OsJMJ703) and a transcription factor ...

The researchers discovered that OsMED23, a component of the cellular "Mediator" complex that helps regulate gene activity ... These three components act as a repressor, reducing the activity ...

Myositis-specific autoantibodies define different subtypes of myositis. For example, patients with anti-Mi2 autoantibodies targeting the chromodomain helicase DNA-binding protein 4 (CHD4)/NuRD complex ...

That rogue scientist who created HIV-resistant designer babies is apparently gearing up for more human gene-editing research. In an interview with the Wall Street Journal, He Jiankui said he ...

Gene Hackman and his wife, Betsy Arakawa, were living on a property infested with rats and mice at the time of their deaths. Rodents, dead and alive, and their nests were discovered in eight detached ...

The core segmentation clock gene, called hairy and enhancer of split 7 (HES7), is a transcription repressor, explained Ebisuya. “If HES7 protein is expressed, it starts repressing its own expression, ...

It’s been one week since Gene Hackman and his wife, Betsy Arakawa, were found dead at their home in Santa Fe, New Mexico, and the investigation is still ongoing as facts and questions continue ...

However, the evidence supporting some of the conclusions remains incomplete, and further mechanistic studies are needed to clarify how miR-283 affects normal aging and influences exercise adaptations.