It provides a novel therapeutic strategy to target RALY for CRC treatment. As previously described,23 RNA immunoprecipitation (RIP) assay was performed using the Magna RIP RNA-Binding Protein ...

This useful study employs AlphaFold2 to predict interactions among 20 nuage proteins, identifying five novel interaction candidates, three of which are validated experimentally through ...

(F) The heterotetramer model of Spn-E_RNA_Squ_Tej predicted by AlphaFold3 ... Scale bars: 10 μm (top row), 2.5 μm (enlarged images) (C) Immunoprecipitation of the endogenous Squ from ovarian lysate ...

Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, ...

Here we identify a novel signaling network centered on the E3 ubiquitin ligase praja2 that controls protein translation in GBM. Praja2 forms a multimeric complex with the RNA helicase DDX6, which ...

Researchers from Boston University Chobanian & Avedisian School of Medicine have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the ...

本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

EPR Laboratory, International Tomography Center SB RAS, 3 Institutskaya Street, Novosibirsk 630090, Russia ...

Alternatively, he said his research is now exploring other avenues to boost the recruitment of the binding protein 53BP1 to replace the function of alpha-synuclein as a possible treatment for ...