The structure of the PP7 bacteriophage coat protein revealed a mode of RNA binding that is distinct from that of the well-characterized MS2 coat protein, suggesting new orthogonal systems for RNA ...

Surprisingly, this family has been robustly identified as novel RNA-binding proteins in numerous crosslinking studies. Subsequent validation of these interactions and the additional observation that ...

Fukunaga and Doudna now show that SGS3 is an RNA-binding protein that specially favors dsRNA with a single-stranded 5′ overhang 1. Their findings suggest that 5′ overhang–containing dsRNA is ...