What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Although there are only a few steps in RNA-Seq (Fig. 1), it does involve several ... not address transcriptome complexity in alternative splicing and transcription termination sites; presumably ...

Overview of RNA repair – There is an emerging appreciation of the existence of ... repairs the ends of the broken tRNA half-molecules. The healing and sealing steps of yeast/plant tRNA splicing ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Spliceosomes are large and dynamic RNA-protein complexes ... At least a dozen other steps are needed before the splicing reaction concludes. Not much is known about how the minor spliceosome ...