RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns ...

as it offers both a refined predictive model and a new tool to designing RNA sequences for targeted splicing outcomes. Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific ...

Emerging evidence suggests that some variants, which are described as missense, synonymous or nonsense variants in the literature or databases, may be deleterious by affecting the pre-mRNA splicing ...

The researchers tested the RNA origami in a lipid vesicle, a simple cell model system widely used in biology. Using so-called RNA aptamers, the artificial cytoskeleton was bound to the cell membranes.

Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth.

“...RNA granule-mediated post-transcriptional and epigenetic alterations in protein expression are remnants of an ancient RNA world...” An important consequence ...

RNA splicing is an essential part of eukaryotic gene expression. Although the mechanism of splicing has been extensively studied in vitro, in vivo kinetics for the two-step splicing reaction remain ...