Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

Spliceosomes are large and dynamic RNA-protein complexes ... step in the spliceosome's complex assembly pathway. At least a dozen other steps are needed before the splicing reaction concludes.

This study shows that RNA decay rather than the presence of premature termination codons triggers a TA-like response.

The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known. Splicing in more complex organisms, like humans ...

A post-splicing complex deposited upstream of each exon-exon junction tags mRNAs for nuclear export ... These nuclear sequence shufflings are implicated increasingly in mechanisms such as RNA-export ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger RNA – a prerequisite for ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...