Biologists have discovered that disruptions in transfer RNA function can lead to the development of cleft lip and cleft palate.

RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Splicing of pre-mRNA requires both high fidelity ... determine the cryo-electron microscopy structures of the PspCas13b–guide RNA complex alone and in complex with target RNA, as well as that ...

The Asian Immune Diversity Atlas (AIDA) single-cell RNA-seq dataset The AIDA ... genetics and drug target discovery for complex diseases related to splicing. Meanwhile, the examples provided ...

Cleft lip and cleft palate are among the most common birth defects, occurring in about one in 1,050 births in the United ...

Ultimately, the spliced messenger RNA consists of only protein-encoding ... It is absolutely vital that the splicing complex accurately recognizes exon-intron-exon junctions so the needed cuts ...

Here, we developed a novel IIC self-splicing introns-derived circular RNA platform and evaluate its potential in vaccine development by ... To assemble the VF-400 and D25 Fab complex, highly purified ...

Cleft lip and cleft palate are among the most common birth defects, occurring in about one in 1,050 births in the United States.

Design We analysed altered gene signatures during colorectal tumour progression, and used a complex of molecular and metabolic assays to study the regulation of metabolism in CRC cell lines, human ...