Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

However, this approach does not address transcriptome complexity in alternative splicing and transcription ... The next big challenge for RNA-Seq is to target more complex transcriptomes to ...

RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known. Splicing in more complex organisms, like humans ...

Gliomas, a type of brain tumor, are notoriously difficult to treat due to their complex genetic makeup ... explored how specific ribonucleic acid (RNA) splicing errors create tumor-specific ...

A post-splicing complex deposited upstream of each exon-exon junction tags mRNAs for nuclear export ... These nuclear sequence shufflings are implicated increasingly in mechanisms such as RNA-export ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...

Ultimately, the spliced messenger RNA consists of only protein-encoding ... It is absolutely vital that the splicing complex accurately recognizes exon-intron-exon junctions so the needed cuts ...