Shah and colleagues take advantage of the presence of maternal and somatic ribosomes in zebrafish and confirm their differential expression during development. The authors convincingly show that ...

DNA and RNA are nucleic acids found in the nucleus ... for genomics and data storage but faces scalability limits due to primer design constraints. Here, the authors present a barcode-based ...

Get Instant Summarized Text (Gist) A computational tool named NuFold has been developed to model 3D RNA structures, potentially accelerating medical discoveries by decades. This tool addresses the ...

自1958年分子生物学“中心法则”被提出以来，各种RNA类型被陆续发现。信使RNA（mRNA）将遗传指令从DNA传递到蛋白质的合成，这一过程持家非编码RNA 促进，例如小核RNA（snRNA）、核糖体RNA（rRNA）和转运RNA（tRNA）。 在过去的四十年中，一系列具有调节基因表达 ...

Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632, China Department of Immunology and Microbiology, College of Life ...

Their study, which was published in Nature Chemical Biology, paves the way for new therapies that can "unfreeze" these RNA structures to combat other mosquito-borne RNA viruses.

Here we report crystal structures of the catalytic core of yeast Pol α in unliganded form, bound to an RNA primer/DNA template and extending an RNA primer with deoxynucleotides. We combine the ...