Scientists have long known that more than 500 genes (out of approximately 20,000 human protein-coding genes) are crucial for DNA repair. By comprehensively analyzing the interactions of these ...

Furthermore, GAF-dependent chromatin openness responded coordinately to population density changes. Fragment mutagenesis abolished henna promoter activity due to the dysfunction of the GAF-binding ...

本研究针对动脉粥样硬化中血管内皮细胞(VECs)损伤机制不明的关键问题，研究人员揭示了RNA结合蛋白IGF2BP3通过特异性结合乳酸脱氢酶A(LDHA)的3'UTR区域稳定其mRNA，从而逆转氧化低密度脂蛋白(ox-LDL)导致的糖代谢抑制，显著减轻内皮细胞凋亡。该发现为心血管疾病 ...

Four primary mechanisms have been elucidated, each involving distinct molecular interactions and regulatory factors: Mechanism I: “RNA-binding protein (RBPs)-driven cyclization ... CircRNA is a closed ...

Deep learning-based in silico modeling (Damayanti et al, 2024) suggested new protein structures and changes in conformation of TFE3 fusion proteins with increased potential for binding DNA, RNA, and ...