A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway. Design Targeted quantitative ...

Conclusion Oxidative stress, especially through purine metabolism pathway, is a major metabolic event during reperfusion and may contribute to the ischaemia reperfusion injury of lung grafts. Data are ...

An additional cyclic pathway for the metabolism of hexose phosphate has recently come to light. This pathway (Fig. 10) appears to function in the synthesis of ascorbic acid, with uronic acids as ...

Therefore, the knockdown of SLC25A1 or ACLY does not appear to affect the myristoylation of FSP1. Further linking the inhibition of the SLC25A1/ACLY-FSP1 pathway to cancer, we investigated the effect ...

Institute of Virology and Biotechnology, State Key Laboratory for Managing Biotic and Chemical Treats to the Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of ...

The purpose of this study was to investigate whether circulating pyruvate kinase M2 (PK‐M2) levels are elevated in the peripheral blood and to assess their association with diagnosis and prognosis in ...

The bioreactor’s efficacy was validated using HeLa and HepG2 cells, demonstrating prolonged cell viability and enhanced metabolic activity in 3D cultures compared to 2D cultures. Hyperpolarized [1-13 ...

Share on Pinterest Is a keto diet or a Mediterranean diet better for blood sugar control, gut health, and weight loss? Design by MNT; Photography by CWP, LLC/Stocksy & Nadine Greeff/Stocksy.

They find this is by metabolic rewiring that shunts pyruvate away from TCA metabolism and into gluconeogenesis. Surprisingly, mTORC and Myc pathways are also hyper-active in this background, despite ...