Age-related changes in immune function increase the susceptibility to many diseases such as infections, autoimmune diseases, and cancer. Different metabolic pathways including glycolysis, ...

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

Emerging reports show that metabolic pathways can be targeted to enhance T cell-mediated immunity to tumors. Yet, tumors consume key metabolites in the host to survive, thus robbing T cells of these ...

An additional cyclic pathway for the metabolism of hexose phosphate has recently come to light. This pathway (Fig. 10) appears to function in the synthesis of ascorbic acid, with uronic acids as ...

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Understanding these shared metabolic pathways opens new avenues for improving both crop resilience and human nutrition. The study focuses on lysine catabolism. Catabolism, the breakdown of ...

Natural ways to boost metabolism can be fun and easy. Simple things like eating more protein, high-intensity interval training, lifting weights, avoiding skipping meals, drinking the right things, ...

The Israelites were near their last encampment and would soon cross the Jordan River to enter into the promised land. Some of them had been children when, with their parents, they had left Egypt; ...

Similarly, for (R)-3-hydroxybutyrate, two of five biological pathways identified from pyruvate were previously reported in literature but seemed inaccessible by ASKCOS and RetroBioCat. ASCKOS ...

However, several Trp metabolism end-products are essential to intestinal homeostasis. Here, we investigated the role of metabolites from the kynurenine pathway. Design Targeted quantitative ...