A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival advantage in the hypoxic ...

DCA is a targeted therapy that inhibits Pyruvate Dehydrogenase Kinase (PDK) to stimulate residual Pyruvate Dehydrogenase Complex (PDC) activity and increase energy (ATP) production by mitochondria.

人前列腺癌细胞PC-3 、DU145 、LNCaP 和人前列腺细胞RWPE-1 （批号SCSP-532 、SCSP-5024 、SCSP-5021 ）由中国科学院典型培养物保藏委员会细胞库提供。 Varioskan ALF 型酶标仪（美国Thermo Fisher Scientific 公司）；PowerPac HC 型电泳仪（美国BioRad 公司）；BX43 型光学显微镜（日本 ...

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(Photo Credit: E+/Getty Images) The lactate dehydrogenase (LDH) test looks for signs of damage to your body’s tissues. Cars need gas or electricity to go. Your cells need an enzyme (proteins ...

A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth and tumorigenesis is emerging beyond Warburg as an area of research that is under-explored in terms of its ...

Correspondence to Dr Ailsa Hart, IBD Unit, St Mark's Hospital and Imperial College London, Watford Road, London HA13UJ, UK; ailsa.hart{at}nhs.net Over the last 10–15 years, our understanding of the ...

And like a good older brother, it helps ensure everyone gets along, offering backward compatibility with all 12-speed AXS components. After about eight months of riding the SRAM RED AXS E1 group, I’m ...

The mouse monoclonal antibody against cyclin-dependent kinase inhibitor 1B (CDKN1B (p27, Kip1)) was from Cell Signaling Technology Inc (Beverly, Massachusetts, USA) and that against glyceraldehyde ...