The study's success demonstrates the potential effectiveness of PASA16 phage therapy in tackling challenging Pseudomonas aeruginosa infections, paving the way for future clinical trials and ...

More information: Ravi K. Lokareddy et al, Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor, Nature Communications (2024). DOI: 10.1038/s41467-024-52752-1.

Unexpectedly, Cingolani and Briani’s study revealed the virion-associated RNA polymerase is part of a genome ejection motor that pulls the DNA of the phage out of its head after the phage has attached ...

The Pseudomonas aeruginosa strain in the outbreak is exceedingly rare and had never before been seen in the U.S. It is especially challenging for doctors to treat given it has developed resistance ...

Researchers describe the full molecular structure of the phage DEV. DEV infects and lyses Pseudomonas aeruginosa bacteria, an opportunistic pathogen in cystic fibrosis and other diseases. DEV ...

Electron microscopy (EM) image of Pseudomonas phage Pf, an inovirus infecting Pseudomonas hosts. Inovirus capsids are long flexible filaments visible here after sample concentration and precipitation.

The viruses that infect bacteria are the most abundant biological entities on the planet. For example, a recent simple study of 92 showerheads and 36 toothbrushes from American bathrooms found more ...

In step one, as a single DEV phage drifts in isolation, its flexible long tail fibers fluctuate to improve the chance of touching a Pseudomonas lipopolysaccharide surface molecule.

New insights into phage therapy design Date: May 15, 2024 Source: The Geisel School of Medicine at Dartmouth Summary: Results from a new study are providing new insights into the therapeutic ...

Integrative structural analysis of Pseudomonas phage DEV reveals a genome ejection motor. Nature Communications , 2024; 15 (1) DOI: 10.1038/s41467-024-52752-1 Cite This Page : ...